A miR-125b/CSF1-CX3CL1/tumor-associated macrophage recruitment axis controls testicular germ cell tumor growth
نویسندگان
چکیده
منابع مشابه
Familial testicular germ cell tumor: no associated syndromic pattern identified
BACKGROUND Testicular germ cell tumor (TGCT) is the most common malignancy in young men. Familial clustering, epidemiologic evidence of increased risk with family or personal history, and the association of TGCT with genitourinary (GU) tract anomalies have suggested an underlying genetic predisposition. Linkage data have not identified a rare, highly-penetrant, single gene in familial TGCT (FTG...
متن کاملGiant Testicular Mixed Germ Cell Tumor
Objective: We report a case that we believe to be the largest example of a testicular mixed germ cell tumor with a clearly defined histology pattern. Clinical Presentation and Interventions: A 21-year-old patient consulted a urologist concerning a giant testicular mass. At the time of presentation the tumor measured 29 ! 20 ! 16 cm, with a weight of 4,850 g. Serum ·-fetoprotein was over 15,000 ...
متن کاملA miR-199a/miR-214 Self-Regulatory Network via PSMD10, TP53 and DNMT1 in Testicular Germ Cell Tumor
It was previously demonstrated that microRNA-199a (miR-199a) was down-regulated in testicular germ cell tumor (TGCT) partially caused by hypermethylation of its promoter. miR-199a is encoded by two loci in the human genome, miR-199a-1 on chromosome (Chr) 19 and miR-199a-2 on Chr 1. Both loci encode the same miR-199a. Another microRNA, microRNA-214 (miR-214), also locates on Chr 1. Previous stud...
متن کاملPure Testicular Teratoma Presenting as a Metastatic Germ Cell Tumor
Mature teratoma comprises 5-10 % of all testicular neoplasms. Pure testicular teratoma is rare in adulthood with an incidence of 5 %. Regardless of differentiation postpubertal testicular teratoma have aggressive behavior and microscopic appearance of metastasis may differ from that of the primary. We present a case of pure teratoma of testis in an adult presenting as a metastatic germ cell tumor.
متن کاملOcclusive Syndrome Revealing a Nonseminoma Germ Cell Tumor Metastatic Testicular
Testicular cancer is rare. The authors report the case of a young Senegalese 21, who has consulted for an occlusive syndrome evolving for 48 hours that prompted his hospitalization. Note that the patient has consulted several times to persistent inguinal scrotal pain, a big right purse with chronic analgesic requirements and anti-inflammatory. Occlusive before this table, abdominal pelvic CT wa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2018
ISSN: 2041-4889
DOI: 10.1038/s41419-018-1021-z